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Developing Peripheral Biochemical Biomarkers of Brain Disorders: Insights from Zebrafish Models
Nikita P Ilyin1, Elena V Petersen2, Tatyana O Kolesnikova3
1Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, 199034, Russia. nik.ilyn.98@gmail.com.
Biochemistry. Biokhimiia
|April 15, 2024
Summary
Zebrafish models offer valuable insights into human brain disorders by revealing peripheral biochemical biomarkers. These findings support zebrafish utility in disease modeling and drug discovery.
Area of Science:
- Neuroscience
- Biochemistry
- Translational Medicine
Background:
- Human brain disorders are prevalent, requiring effective diagnostic and monitoring tools.
- Peripheral biomarkers are crucial for understanding and tracking brain diseases.
- Animal models, particularly zebrafish, are vital for studying brain disorder pathogenesis.
Purpose of the Study:
- To review evidence on peripheral biochemical biomarkers in zebrafish models of brain disorders.
- To highlight the utility of zebrafish in studying systemic manifestations of neurological conditions.
- To explore the application of zebrafish-derived biomarkers in drug discovery.
Main Methods:
- Review of existing literature on peripheral biomarkers in zebrafish models.
- Focus on biochemical alterations including lipids, carbohydrates, proteins, and enzyme activity.
- Analysis of studies examining neurobehavioral and metabolic phenotypes.
Main Results:
- Zebrafish exhibit conserved phenotypes relevant to human brain disorders.
- Altered peripheral biochemistry in zebrafish models reflects brain pathogenesis.
- Evidence supports zebrafish as a model for identifying systemic disease indicators.
Conclusions:
- Zebrafish are a powerful model organism for studying peripheral manifestations of brain disorders.
- Peripheral biochemical biomarkers in zebrafish have significant potential for diagnostics and disease monitoring.
- Zebrafish models can accelerate biomarker-based drug discovery and development for neurological conditions.
