Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study
02:35

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

794

Deciphering programmed cell death mechanisms in osteosarcoma for prognostic modeling.

Jingyang Chen1, Tengdi Fan1, Lingxiao Pan1

  • 1Department of Orthopedics, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China.

Environmental Toxicology
|April 16, 2024
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Substance P-expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus-airway neural pathway.

Frontiers in neuroscience·2026
Same author

Concurrent Hydrolysis Resistance and High Thermal Conductivity in Aluminum Nitride Enabled by Phase-Engineered Graphene Encapsulation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Effects of Environmental Factors on Incidence of Allergic Rhinitis and Chronic Rhinosinusitis: A Comparative Study.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Exploring the gut microbiome and metabolomic interactions of antimetabolite drugs to optimize therapy.

Gut microbes·2026
Same author

Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Oxidative Dissolution Effects on Shale Pore Structure, Mechanical Properties, and Gel-Breaking Performance.

Gels (Basel, Switzerland)·2025

This study reveals key programmed cell death (PCD) genes in osteosarcoma (OS) and develops a bioinformatics model to predict patient outcomes, aiding in the development of targeted therapies for this challenging cancer.

Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • Osteosarcoma (OS) is characterized by high rates of recurrence and metastasis, presenting a significant clinical challenge.
  • Understanding the molecular mechanisms, including programmed cell death (PCD), is crucial for improving OS treatment outcomes.

Purpose of the Study:

  • To investigate the role of PCD genes in osteosarcoma.
  • To develop and validate a prognostic model for OS based on PCD-related genes using bioinformatics approaches.

Main Methods:

  • Analysis of single-cell and bulk sequencing data from public databases (GEO, TARGET).
  • Application of consistency clustering, Kaplan-Meier survival analysis, and ssGSEA for PCD score calculation.
  • Identification of differentially expressed genes, GO/KEGG enrichment analysis, and immune cell infiltration analysis.
Keywords:
GEOTARGETmachine learningosteosarcomaprogrammed cell death

More Related Videos

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.2K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K

Related Experiment Videos

Last Updated: Jun 28, 2025

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study
02:35

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

794
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.2K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.2K
  • Development and validation of a prognostic model using LASSO regression.

    • Main Results:

    • Identification of distinct cell subpopulations and PCD gene distribution in OS.
    • Development of a robust prognostic model based on five genes (BAMBI, TMCC2, NOX4, DKK1, CBS) with significant predictive accuracy.
    • Insights into PCD pathways, drug sensitivity, and immune microenvironment in OS.

    Conclusions:

    • The developed prognostic model enhances the understanding of PCD's role in OS progression.
    • This research provides a foundation for developing novel therapeutic strategies targeting PCD pathways in osteosarcoma.