Related Experiment Video

Updated: Jun 28, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.1K

Susceptibility of optic nerve head in children with posture-related elevation of intraocular pressure

Jan Niklas Lüke1, Caroline Gietzelt2, Philip Enders2

  • 1Department of Ophthalmology, Medical Faculty and University Hospital of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany. jan.lueke@uk-koeln.de.

International Ophthalmology
|April 16, 2024
PubMed

Insights

No significant changes in optic nerve head (ONH) morphometry were observed in children with high nocturnal intraocular pressure (IOP). Posture-dependent IOP elevations did not impact retinal nerve fiber layer thickness or Bruch membrane opening measurements over four years.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Glaucoma Research

Background:

  • Nocturnal intraocular pressure (IOP) elevations can pose a risk to optic nerve head (ONH) health.
  • Understanding the impact of these elevations on ONH morphometry in children is crucial for early detection and management.

Purpose of the Study:

  • To investigate changes in ONH morphometry in children experiencing significant nocturnal IOP elevations.
  • To assess the influence of posture-dependent IOP on Bruch membrane opening (BMO)-based measurements.

Main Methods:

  • Longitudinal analysis of ONH morphometry using SD-OCT in 32 children (<18 years) with nocturnal IOP > 25 mmHg.
  • Measurements included Bruch Membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness.
  • Evaluated changes at 1-year and 4-year follow-ups.

Main Results:

  • No significant changes in global BMO-MRW or RNFL thickness were observed at 1-year or 4-year follow-ups.
  • Neither 1-year nor 4-year BMO-MRW or RNFL measurements differed significantly from baseline.
  • Absolute supine IOP values did not correlate with changes in BMO-MRW or RNFL thickness.

Conclusions:

  • Posture-dependent IOP elevations do not appear to influence ONH morphometric parameters in children.
  • Retinal nerve fiber layer thickness and BMO-based morphometry remain stable despite significant nocturnal IOP elevations in this pediatric cohort.
  • Further research may explore other contributing factors to ONH changes in pediatric glaucoma.
Abstract

Keywords:
Bruch membrane openingChildrenGlaucomaIntraocular pressurePosture-relatedRebound tonometry

More Related Videos

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition06:09

Optic Nerve Sheath Point of Care Ultrasound: Image Acquisition

Published on: August 18, 2023

1.5K
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye09:03

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye

Published on: June 20, 2015

10.0K

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
560
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
440
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
485
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.5K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K