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Factors associated with venous collaterals in patients with cerebral venous thrombosis

Phirat Petchprom1, Nuttha Sanghan2, Rujimas Khumthong2

  • 1Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.

Plos One
|April 16, 2024
PubMed

Insights

Venous collaterals are present in 25.3% of Thai patients with cerebral venous thrombosis. Superior sagittal sinus occlusion and hormonal exposure are independent factors associated with venous collaterals.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) is a rare but serious condition.
  • Venous collaterals play a crucial role in venous drainage of the brain.
  • Identifying factors associated with venous collaterals in CVT is important for understanding disease pathophysiology and prognosis.

Purpose of the Study:

  • To identify factors associated with the presence of venous collaterals in Thai patients diagnosed with cerebral venous thrombosis.
  • To determine the prevalence of venous collaterals in this patient cohort.

Main Methods:

  • A retrospective 20-year cohort study of patients diagnosed with CVT.
  • Data collected from electronic medical records.
  • Venous collaterals assessed by two neuroradiologists using the Qureshi classification.
  • Univariate and multivariate logistic regression analyses performed to identify associated factors.

Main Results:

  • The prevalence of venous collaterals was 25.3% among 79 CVT patients.
  • Patients with venous collaterals were younger and more likely to have superior sagittal sinus occlusion and hormonal exposure.
  • Multivariate analysis identified superior sagittal sinus occlusion (aOR 3.581) and hormonal exposure (aOR 7.276) as independent factors associated with venous collaterals.

Conclusions:

  • Venous collaterals are present in approximately a quarter of Thai patients with CVT.
  • Occlusion of the superior sagittal sinus and hormonal exposure are independently associated with the development of venous collaterals in CVT.
  • These findings contribute to understanding the compensatory mechanisms in CVT.
Abstract

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