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Generating robust aptamers for food analysis by sequence-based configuration optimization.

Kaiyue Wei1, Ziyang Ye1, Wenhui Dong1

  • 1State Key Laboratory of Marine Food Processing and Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266404, PR China; Qingdao Key Laboratory of Food Biotechnology, Qingdao, 266404, PR China; Key Laboratory of Biological Processing of Aquatic Products, China National Light Industry, 266404, PR China.

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Summary
This summary is machine-generated.

This review focuses on enhancing aptamers for food analysis. Sequence-based optimization improves aptamer affinity and specificity for reliable biosensor development, ensuring food safety.

Keywords:
AptamerAptasensorFood analysisSequence-based configuration optimization

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Area of Science:

  • Food Science
  • Analytical Chemistry
  • Biotechnology

Background:

  • Aptamer-based biosensors offer rapid, selective food analysis.
  • Systematic Evolution of Ligands by EXponential Enrichment (SELEX) screens aptamers.
  • Initial SELEX may yield aptamers with insufficient binding affinity.

Purpose of the Study:

  • To review sequence-based optimization strategies for aptamers in food analysis (2015-2023).
  • To highlight robust aptamers and aptasensors developed for food targets.
  • To inspire high-performance aptamer and aptasensor development for food quality and safety.

Main Methods:

  • Focus on post-SELEX sequence-based optimization strategies.
  • Review of aptamer generation and aptasensor development for food applications.
  • Analysis of studies published between 2015 and 2023.

Main Results:

  • Sequence-based optimization enhances aptamer configuration and binding affinity.
  • Specificity of optimized aptamers is confirmed.
  • Various aptamers and aptasensors have been successfully developed for food targets.

Conclusions:

  • Sequence-based optimization is a valuable post-SELEX strategy.
  • Optimized aptamers show great potential for advanced food analysis.
  • This approach contributes to safeguarding food quality and safety.