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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Frailty and psychiatric disorders: A bidirectional Mendelian randomization study.

Jie-Hai Chen1, Hang Lei2, Yu-Fei Wan2

  • 1Department of Anesthesiology, Nanfang Hospital, Southern Medical University; Guangdong Provincial Key Laboratory of Precision Anaesthesia and Perioperative Organ Protection, Guangzhou, Guangdong 510515, China; Dongguan Maternal and Child Health Care Hospital, Dongguan, 523125, Guangdong, China.

Journal of Affective Disorders
|April 16, 2024
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Summary

This study found that frailty and major depressive disorder (MDD) and neuroticism causally influence each other. Genetically predicted frailty also increases the risk of anxiety disorder in older adults.

Keywords:
Causal relationshipFrailty indexMendelian randomizationOlder peoplePsychiatric disorders

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Area of Science:

  • Gerontology
  • Psychiatry
  • Genetics

Background:

  • Observational studies suggest a link between frailty and psychiatric disorders.
  • Causality between frailty and psychiatric disorders remains unclear.

Purpose of the Study:

  • To investigate the bidirectional causal relationship between frailty and psychiatric disorders using Mendelian randomization.

Main Methods:

  • Utilized genetic variants from large genome-wide association studies (GWAS) for frailty index (FI) and psychiatric disorders.
  • Employed inverse variance weighted (IVW) method for primary causal effect estimation.
  • Conducted sensitivity analyses and multivariable analyses for robustness.

Main Results:

  • Genetically predicted FI was associated with increased risk of major depressive disorder (MDD), anxiety disorder, and neuroticism.
  • Genetic liability to MDD and neuroticism was associated with higher FI.
  • Multivariable analyses confirmed bidirectional causality between FI and MDD/neuroticism.

Conclusions:

  • Established a bidirectional causal link between frailty, MDD, and neuroticism.
  • Demonstrated that genetically predicted frailty increases anxiety disorder risk.
  • Highlights the need for integrated management of frailty and mental health in older adults.