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Updated: May 12, 2026
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Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
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Nomogram for predicting early hypophosphatemia in term infants.
Wan Tao1, Shina Zhan1, Yingjie Shen1
1Neonatal Center, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, No.1 Shunkang Road, Shunyi District Beijing, Beijing, 101300, China.
BMC Pediatrics
|April 16, 2024
Summary
We developed a nomogram to predict early hypophosphatemia in newborns. This tool identifies risk factors like male sex, maternal diabetes, and lower birth weight for timely intervention.
Area of Science:
- Neonatal Medicine
- Biochemistry
- Pediatric Endocrinology
Background:
- Phosphate is vital for physiological processes, including energy production via adenosine triphosphate (ATP).
- Hypophosphatemia, a condition of low phosphate levels, can impact multiple organ systems.
- Early detection and supplementation are crucial for newborns with hypophosphatemia risk factors.
Purpose of the Study:
- To identify risk factors associated with early-onset hypophosphatemia in term infants.
- To develop and validate a predictive nomogram for early hypophosphatemia in this population.
Main Methods:
- Retrospective study of 416 term infants, comparing 82 with hypophosphatemia (HP group) to 334 without (NHP group).
- Data collected included maternal, neonatal, and delivery characteristics.
- Logistic regression analysis identified independent risk factors; a nomogram was constructed and validated.
Main Results:
- Independent risk factors for early hypophosphatemia included male sex, maternal diabetes, cesarean delivery, lower serum magnesium, and lower birth weight.
- The developed nomogram demonstrated good predictive ability with a C-index of 0.732.
- Calibration curves and decision curve analysis confirmed the nomogram's clinical utility.
Conclusions:
- A validated nomogram for predicting early hypophosphatemia in term infants has been successfully developed.
- This tool can aid in the early identification and management of hypophosphatemia in newborns.
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