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Biochemical Measurement of Neonatal Hypoxia
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Nomogram for predicting early hypophosphatemia in term infants

Wan Tao1, Shina Zhan1, Yingjie Shen1

  • 1Neonatal Center, Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, No.1 Shunkang Road, Shunyi District Beijing, Beijing, 101300, China.

BMC Pediatrics
|April 16, 2024
PubMed

Insights

We developed a nomogram to predict early hypophosphatemia in newborns. This tool identifies risk factors like male sex, maternal diabetes, and lower birth weight for timely intervention.

Area of Science:

  • Neonatal Medicine
  • Biochemistry
  • Pediatric Endocrinology

Background:

  • Phosphate is vital for physiological processes, including energy production via adenosine triphosphate (ATP).
  • Hypophosphatemia, a condition of low phosphate levels, can impact multiple organ systems.
  • Early detection and supplementation are crucial for newborns with hypophosphatemia risk factors.

Purpose of the Study:

  • To identify risk factors associated with early-onset hypophosphatemia in term infants.
  • To develop and validate a predictive nomogram for early hypophosphatemia in this population.

Main Methods:

  • Retrospective study of 416 term infants, comparing 82 with hypophosphatemia (HP group) to 334 without (NHP group).
  • Data collected included maternal, neonatal, and delivery characteristics.
  • Logistic regression analysis identified independent risk factors; a nomogram was constructed and validated.

Main Results:

  • Independent risk factors for early hypophosphatemia included male sex, maternal diabetes, cesarean delivery, lower serum magnesium, and lower birth weight.
  • The developed nomogram demonstrated good predictive ability with a C-index of 0.732.
  • Calibration curves and decision curve analysis confirmed the nomogram's clinical utility.

Conclusions:

  • A validated nomogram for predicting early hypophosphatemia in term infants has been successfully developed.
  • This tool can aid in the early identification and management of hypophosphatemia in newborns.
Abstract

Keywords:
Birth weightCesarean deliveryHypophosphatemiaMaleMaternal diabetesNomogramSerum magnesium

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