Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Functions of the Lymphatic and Immune System

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

What is the Immune System?

What is the Immune System?

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

Cross-reactivity

Cross-reactivity

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

Introduction to Innate and Adaptive Immunity

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrating the Contrasting Perspectives Between the Constrained Disorder Principle and Deterministic Optical Nanoscopy: Enhancing Information Extraction from Imaging of Complex Systems.

Bioengineering (Basel, Switzerland)·2026

Same author

The Constrained Disorder Principle: A Paradigm Shift for Accurate Interactome Mapping and Information Analysis in Complex Biological Systems.

Bioengineering (Basel, Switzerland)·2025

Same author

Employing an Artificial Intelligence Platform to Enhance Treatment Responses to GLP-1 Agonists by Utilizing Metabolic Variability Signatures Based on the Constrained Disorder Principle.

Biomedicines·2025

Same author

A constrained disorder principle-based second-generation artificial intelligence digital medical cannabis system: A real-world data analysis.

Journal of public health research·2025

Same author

The Constrained Disorder Principle: Beyond Biological Allostasis.

Biology·2025

Same author

The Relationship Between Biological Noise and Its Application: Understanding System Failures and Suggesting a Method to Enhance Functionality Based on the Constrained Disorder Principle.

Biology·2025

Search research articles

Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

Correlations between components of the immune system.

Yehudit Shabat¹, Yaron Ilan¹

¹Hadassah University Hospital, Jerusalem, Jerusalem, Israel, Israel.

|April 17, 2024

Summary

Fasting and splenectomy can alter immune cell markers and cytokine secretion in mice at a distance. This suggests a novel way to induce immune system correlations without direct mediator transfer.

Keywords:

complex systems; immune memory; information transfer; immune response; randomness

More Related Videos

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Jun 28, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

Area of Science:

Immunology
Cell Biology
Systems Biology

Background:

Limited understanding of how to modulate immune components without affecting associated parts.
Previous research has not demonstrated the possibility of altering immune system constituents independently.

Purpose of the Study:

To investigate the effects of fasting and splenectomy on immune cell expression and cytokine secretion.
To explore the potential for inducing immune system correlations at a distance.

Main Methods:

Developed a schematic model to study fasting and splenectomy as triggers.
Analyzed changes in cell membrane epitopes and cytokine secretion of lymphocytes.
Compared splenectomized and non-splenectomized mice under fasting and non-fasting conditions.
Assessed the impact of keeping cells in an out-of-body location.

Main Results:

Fasting decreased CD8 and CD25 expression while increasing TNFα.
Splenectomy in non-fasting mice increased CD8 expression and TNFα, IFNg, and IL10 secretion.
Splenectomy in fasting mice significantly altered CD25, CD4 CD25 expression, and TNFα, IFNg, IL10 secretion.
Out-of-body conditions induced significant changes in CD8 expression and decreased TNFα and IFNg secretion.

Conclusions:

Fasting and splenectomy can remotely influence immune cell surface markers and cytokine profiles.
Demonstrated a system for inducing immune system correlations without mediator transfer.
Suggests the possibility of inducing out-of-body correlations between immune system components.