Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.4K
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.2K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.2K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

6.4K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
6.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating the Contrasting Perspectives Between the Constrained Disorder Principle and Deterministic Optical Nanoscopy: Enhancing Information Extraction from Imaging of Complex Systems.

Bioengineering (Basel, Switzerland)·2026
Same author

Employing an Artificial Intelligence Platform to Enhance Treatment Responses to GLP-1 Agonists by Utilizing Metabolic Variability Signatures Based on the Constrained Disorder Principle.

Biomedicines·2025
Same author

A constrained disorder principle-based second-generation artificial intelligence digital medical cannabis system: A real-world data analysis.

Journal of public health research·2025
Same author

The Constrained Disorder Principle: Beyond Biological Allostasis.

Biology·2025
Same author

The Relationship Between Biological Noise and Its Application: Understanding System Failures and Suggesting a Method to Enhance Functionality Based on the Constrained Disorder Principle.

Biology·2025
Same author

Variability in Exercise is Linked to Improved Age-related Dysfunctions, Suggesting a Potential Role for the Constrained-Disorder Principle-based Second-Generation Artificial Intelligence System.

Current aging science·2025

Related Experiment Video

Updated: Jan 10, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

532

The Constrained Disorder Principle: A Paradigm Shift for Accurate Interactome Mapping and Information Analysis in

Yaron Ilan1

  • 1Department of Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel.

Bioengineering (Basel, Switzerland)
|November 27, 2025
PubMed
Summary

The Constrained Disorder Principle (CDP) enhances interactome models by integrating biological variability and noise. This approach improves the predictive power and relevance of dynamic, context-dependent molecular interaction maps.

Keywords:
biological variabilityconstrained disorder principledynamic networksinteractomemolecular interactionsnetwork physiologystochastic processessystems biology

More Related Videos

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.6K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
09:39

Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

532
JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

3.6K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

2.9K

Area of Science:

  • Systems Biology
  • Bioinformatics
  • Molecular Biology

Background:

  • The interactome, a network of molecular interactions, is vital for understanding cellular functions and diseases.
  • Current interactome models are limited by their inability to capture biological systems' inherent variability and randomness.
  • Physiological variability and biological noise are often treated as artifacts, hindering model accuracy.

Purpose of the Study:

  • To introduce the Constrained Disorder Principle (CDP) as a novel framework for enhancing interactome models.
  • To demonstrate how integrating physiological variability and biological noise improves model accuracy and predictive power.
  • To shift from static network representations to dynamic, context-dependent interaction maps.

Main Methods:

  • Analysis of existing clinical data and theoretical frameworks.
  • Examination of the Constrained Disorder Principle's application to interactome modeling.
  • Development of methodological advances for incorporating controlled variability.

Main Results:

  • The CDP offers a method to integrate variability and noise into interactome models.
  • Incorporating controlled variability enhances the predictive power and biological relevance of interactome models.
  • Evidence supports the functional importance of biological variability across molecular, cellular, and organ levels.

Conclusions:

  • The Constrained Disorder Principle provides a more accurate representation of biological systems by embracing variability.
  • Dynamic, context-dependent interaction maps derived from the CDP better reflect the complexity of living systems.
  • Methodological advances are proposed to leverage the CDP for improved biological insights.