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Updated: Jun 28, 2025
10:49
Measuring RAN Peptide Toxicity in C. elegans
Published on: April 30, 2020
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Mapping of repeat-associated non-AUG (RAN) translation knowledge: A bibliometric analysis
Taiqi Zhao1,2, Suying Duan1,2, Jiaqi Li1,2
1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Heliyon
|April 17, 2024
Summary
Repeat-associated non-AUG (RAN) translation generates disease-causing proteins from expanded microsatellites. This bibliometric analysis maps the research landscape, highlighting key topics and emerging trends in RAN translation studies.
Area of Science:
- Genetics
- Molecular Biology
- Biochemistry
Background:
- Over 50 genetic human disorders are linked to irregular microsatellite expansions.
- Expanded microsatellites can lead to novel protein synthesis via repeat-associated non-AUG (RAN) translation.
- A gap exists in comprehensive literature reviews on RAN translation.
Purpose of the Study:
- To conduct a bibliometric analysis of RAN translation research.
- To evaluate the current landscape and progress of RAN translation studies.
- To identify key research hotspots and trends.
Main Methods:
- Literature search on Web of Science Core Collection.
- Bibliometric analysis using CiteSpace and VOSviewer.
- Analysis of publications, journals, authors, institutions, countries, keywords, and references (2011-2022).
Main Results:
- 250 publications from 34 countries/regions, 359 institutions, and 1317 authors were analyzed.
- C9orf72-related amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) mechanisms are central research topics.
- Cellular stress and small molecule utilization are identified as trending research areas.
Conclusions:
- This study provides a systematic overview of RAN translation research.
- The findings highlight the significance of C9orf72 in RAN translation.
- Emerging trends indicate a growing focus on cellular stress and therapeutic interventions.
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