[How to determine the prophylactic effect on postoperative infections].

Area of Science:

• Gynecological Surgery
• Infectious Disease Prevention
• Pharmacology

Context:

• Postoperative infections are a significant concern in gynecological surgery.
• Evaluating prophylactic antibiotic efficacy is crucial for patient outcomes.
• This study focused on abdominal and vaginal hysterectomies in the Tokyo area.

Purpose:

• To assess the prophylactic effect of cefotiam (CTM) on postoperative infections.
• To evaluate febrile morbidity and fever index as indicators of infection.
• To determine the efficacy of a 3-5 day postoperative CTM regimen.

Summary:

• A study involving 299 patients undergoing hysterectomy evaluated cefotiam (CTM) for infection prophylaxis.
• Postoperative infection rates were 5.1% for abdominal and 4.2% for vaginal hysterectomy.
• Febrile morbidity and fever index were significantly higher in the infection group, indicating CTM's prophylactic effect.

Impact:

• Febrile morbidity and fever index serve as reliable indicators for assessing antibiotic prophylaxis effectiveness.
• The findings support the use of cefotiam in preventing postoperative infections in gynecological procedures.
• This research contributes to optimizing antibiotic strategies in surgical settings.