Related Experiment Video
Updated: Jun 28, 2025
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
The effect of actuation frequency on clot integration with the Tigertriever device: A preliminary in vitro study
Chander Sadasivan1, Nakisa Dashti1, Megha Gopal1
1Department of Neurological Surgery, Stony Brook University, Stony Brook, NY, USA.
Background:
The Tigertriever stent retriever (Rapid Medical) can be actively expanded and contracted by the operator, which allows for several actuation-related parameters to be optimized to potentially improve device efficacy. These parameters have not yet been evaluated. We conducted a benchtop study to evaluate the effect of actuation frequency on clot integration within the stent.
Methods:
A Tigertriever 17 device was deployed within a biological clot analog placed in a straight tube. The device was actuated between the maximally contracted and maximally expanded states with three different frequencies: passive (one-time opening, n = 6), slow (20 s/cycle, n = 6), and fast (5 s/cycle, n = 7). A flat-detector CT scan was acquired, the clot and stent wires were segmented, and the boundaries of the clot and stent wires were calculated on each axial slice. The intersection between the stent and clot boundaries throughout the volume was defined as the volume of clot integrated within the stent. The clot integration factor (ratio of integrated clot volume to total clot volume) was then statistically compared between the three frequencies as an estimate of clot capture efficiency.
Results:
The clot integration factor was significantly higher (23% increase, p = 0.01) with the fast actuation as compared to the passive and slow actuations, with a post hoc test showing no difference (p > 0.05) between the passive and slow groups.
Conclusions:
Faster actuation frequencies may result in improved clot integration with the Tigertriever device. This effect needs to be validated by clinical data.
