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Updated: Jun 28, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
Published on: May 25, 2018
Deconstructing cancer with precision genome editing
Grace A Johnson1,2, Samuel I Gould1,2, Francisco J Sánchez-Rivera1,2
1Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, MA, U.S.A.
Abstract:
Recent advances in genome editing technologies are allowing investigators to engineer and study cancer-associated mutations in their endogenous genetic contexts with high precision and efficiency. Of these, base editing and prime editing are quickly becoming gold-standards in the field due to their versatility and scalability. Here, we review the merits and limitations of these precision genome editing technologies, their application to modern cancer research, and speculate how these could be integrated to address future directions in the field.
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