Related Experiment Video

Updated: May 8, 2026

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
10:25

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Published on: January 23, 2018

21.4K

Generating Homogeneous Brain Organoids from Human iPSCs

Xianwei Chen1, Yanhong Shi2

  • 1Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, Duarte, CA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 17, 2024
PubMed

Keywords:
Alzheimer’s diseaseBrain organoidsDifferentiationDisease modelingEmbryoid bodies (EBs)Induced pluripotent stem cells (iPSCs)Neurological diseasesPluripotent stem cells (PSCs)

More Related Videos

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells08:30

A Static Self-Directed Method for Generating Brain Organoids from Human Embryonic Stem Cells

Published on: March 4, 2020

8.8K
Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors10:16

Brain Organoid Generation from Induced Pluripotent Stem Cells in Home-Made Mini Bioreactors

Published on: December 11, 2021

5.5K

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...