Related Experiment Video

Updated: Jun 28, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.1K

Complicated pneumonia caused by group A Streptococcus in children - 2022/2023 infectious season outbreak and update

Magdalena Grochowska1, Agnieszka Strzelak2, Katarzyna Krenke2

  • 1Department of Pediatric Pulmonology and Allergy, Medical University of Warsaw, Warsaw, Poland; Doctoral School, Medical University of Warsaw, Warsaw, Poland.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|April 17, 2024
PubMed

Insights

Group A Streptococcus (GAS) is the leading cause of complicated pediatric pneumonia post-pandemic. Early recognition of scarlet fever symptoms and viral infections is crucial for managing this severe condition.

Area of Science:

  • Pediatric Infectious Diseases
  • Respiratory Medicine
  • Microbiology

Background:

  • Increased incidence of Group A Streptococcus (GAS) infections in children post-COVID-19 pandemic.
  • Limited data on GAS contribution to complicated community-acquired pneumonia (CAP).
  • Need to understand pulmonary manifestations of GAS in pediatric populations.

Purpose of the Study:

  • To determine the role of GAS in complicated CAP in children.
  • To analyze the clinical presentation and outcomes of GAS-related complicated CAP.
  • To assess GAS as a cause of pediatric pneumonia during the 2022/2023 season.

Main Methods:

  • Retrospective analysis of complicated CAP cases in hospitalized children.
  • Study conducted at a tertiary care center in Warsaw, Poland.
  • Inclusion period: August 2022 to May 2023.

Main Results:

  • GAS was the dominant pathogen in complicated CAP (24.2%).
  • GAS pneumonia cases often presented with scarlet fever (68.2%) and viral infections (27.3%).
  • GAS complicated CAP involved longer hospitalization and more chest tube insertions, but shorter drainage duration; associated with higher procalcitonin and lower platelets.

Conclusions:

  • Group A Streptococcus is the predominant pathogen causing complicated CAP in children.
  • Clinicians must recognize the current epidemiology and potential severity of GAS pneumonia.
  • Close monitoring is advised for children with scarlet fever and preceding viral infections.
Abstract

Keywords:
Community-acquired pneumoniaEmpyemaGASNecrotizing pneumoniaPleural effusion

More Related Videos

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/4306:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

1.7K
Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae09:12

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

12.4K

Related Concept Videos

Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
205
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
230
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
262
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.0K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
324
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
624