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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

173
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
173
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

156
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
156
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

199
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
199
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

170
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
170
Pneumothorax-I01:26

Pneumothorax-I

202
A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.
202
Pneumothorax-II01:27

Pneumothorax-II

141
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
141

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Related Experiment Video

Updated: Jun 28, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

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Emergencies in Pulmonary Hypertension.

Sanjeeb Bhattacharya1

  • 1Section of Heart Failure and Cardiac Transplantation, Cleveland Clinic, 9500 Euclid Avenue, Suite J3-4, Cleveland, OH 44195, USA.

Cardiology Clinics
|April 17, 2024
PubMed
Summary

Managing pulmonary arterial hypertension (WHO Group 1) in critical care is complex. Prompt, multidisciplinary care at specialized centers is vital for optimizing treatment and reducing high mortality risks.

Area of Science:

  • Cardiology
  • Pulmonology
  • Critical Care Medicine

Background:

  • Pulmonary hypertension presents diverse etiologies.
  • Pulmonary arterial hypertension (WHO Group 1) management is particularly challenging in critical care.
  • High morbidity and mortality risks necessitate specialized care.

Purpose of the Study:

  • To outline the critical care management of pulmonary arterial hypertension.
  • To emphasize the need for a multidisciplinary approach and specialized facilities.
  • To guide treatment strategies for acute decompensated right heart failure in this population.

Main Methods:

  • Review of current management strategies for pulmonary arterial hypertension in critical care.
  • Focus on multidisciplinary team collaboration and specialized care facilities.
Keywords:
Critical careEmergenciesPAHPulmonary hypertension

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A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
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A Large Animal Model for Pulmonary Hypertension and Right Ventricular Failure: Left Pulmonary Artery Ligation and Progressive Main Pulmonary Artery Banding in Sheep
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  • Emphasis on hemodynamic optimization and pulmonary vasodilator therapy.

    • Main Results:

    • Effective management requires a comprehensive evaluation and rapid treatment initiation.
    • Optimizing preload and afterload is crucial for acute decompensated right heart failure.
    • Tailored treatment based on specialized situations improves outcomes.

    Conclusions:

    • Pulmonary arterial hypertension management demands a specialized, multidisciplinary approach.
    • Critical care interventions should focus on hemodynamic support and targeted therapies.
    • Careful patient evaluation is key to successful treatment and improved survival.