Coronary Microvascular Disease Registry (CMDR): Study design and rationale

Area of Science:

• Cardiology
• Vascular Biology
• Clinical Research

Background:

• Coronary microvascular dysfunction (CMD) affects many patients with cardiovascular risk factors, impacting quality of life and increasing adverse events.
• Current understanding of CMD's natural history is limited due to insufficient data.
• Novel invasive diagnostic techniques for CMD are emerging.

Purpose of the Study:

• To standardize comprehensive coronary functional testing for CMD.
• To understand the natural history and clinical outcomes of patients with CMD.
• To improve diagnostic and treatment strategies for CMD.

Main Methods:

• Prospective, multicenter registry (Coronary Microvascular Disease Registry - CMDR).
• Enrollment of consecutive subjects undergoing invasive hemodynamic assessment and acetylcholine provocation tests.
• Follow-up assessments at 30 days and annually for up to 5 years, monitoring angina grade, mortality, MIs, strokes, and other clinical outcomes.

Main Results:

• Data not yet available as the study is ongoing.
• The registry aims to collect comprehensive longitudinal data on CMD patients.

Conclusions:

• The CMDR registry will characterize the clinical and physiological profile of patients undergoing invasive coronary functional testing.
• Longitudinal data will elucidate the natural history and outcomes of CMD.
• Findings are expected to enhance diagnostic and treatment strategies, improving prognosis and quality of life for CMD patients.