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Updated: Jun 28, 2025

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Study protocol: exercise training for treating major depressive disorder in multiple sclerosis.

Robert W Motl1, Charles H Bombardier2, Jennifer Duffecy3

  • 1Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, 60612, USA. robmotl@uic.edu.

BMC Neurology
|April 17, 2024
PubMed
Summary
This summary is machine-generated.

Home-based exercise training shows promise for reducing depression in multiple sclerosis patients. This intervention may offer sustained benefits for managing major depressive disorder symptoms and improving quality of life.

Keywords:
Behavior changeDepressionExerciseMental healthMoodMultiple sclerosisNeurological diseasePhysical activityTelehealth

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Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Major depressive disorder (MDD) is common and undertreated in multiple sclerosis (MS) patients.
  • Exercise training is a potential therapeutic strategy for MDD in individuals with MS.

Purpose of the Study:

  • To evaluate the effectiveness of a 4-month home-based exercise training intervention on depression severity in persons with MS and MDD.
  • To assess the maintenance of depression reduction during a follow-up period.

Main Methods:

  • A parallel-group, assessor-blinded randomized controlled trial (RCT) involving 146 participants with MS and MDD.
  • Participants were randomized to either a home-based exercise training group or a stretching attention control group.
  • Interventions were delivered remotely over 4 months, with 8 virtual coaching sessions, and outcomes assessed at 0, 4, and 8 months.

Main Results:

  • The study hypothesizes a significant reduction in depression severity immediately after the exercise intervention compared to the control group.
  • It is predicted that this reduction in depression will be sustained throughout the 8-month follow-up period.

Conclusions:

  • This study aims to provide Class I evidence for home-based exercise programs in treating MDD among MS patients.
  • Successful outcomes could lead to exercise training's integration into MS clinical management, potentially improving symptoms, cognition, and quality of life.