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Related Experiment Video

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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
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The HUC progression score: A new method for determining KERATOCONUS progression.

Beatriz de Luis Eguileor1, Borja Santos Zorrozúa2, Jaime Etxebarria Ecenarro1

  • 1Deparment of Ophthalmology, BioCruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo, Spain.

European Journal of Ophthalmology
|April 18, 2024
PubMed
Summary

A new keratoconus progression score, considering Pentacam HR repeatability, identifies fewer patients needing crosslinking. This score accurately evaluates corneal changes and aberrations, aiding in treatment decisions for keratoconus progression.

Keywords:
CORNEA / EXTERNAL DISEASEcorneal degenerations < CORNEA / EXTERNAL DISEASEexamination techniques: corneal topography/Keratometry < CORNEA / EXTERNAL DISEASEexamination techniques: pachimetry < CORNEA / EXTERNAL DISEASEexamination techniques < CORNEA / EXTERNAL DISEASE

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Area of Science:

  • Ophthalmology
  • Corneal Disease
  • Diagnostic Imaging

Background:

  • Keratoconus is a progressive corneal ectasia.
  • Accurate assessment of keratoconus progression is crucial for timely intervention.
  • Existing criteria may not fully account for measurement variability.

Purpose of the Study:

  • To establish new criteria for keratoconus progression.
  • To incorporate the repeatability limit of the Pentacam HR (high resolution) tomographer.
  • To develop a more precise score for evaluating keratoconus evolution.

Main Methods:

  • Retrospective observational study of 224 eyes in 154 keratoconus patients.
  • Analysis of a new keratoconus progression score from Cruces University Hospital.
  • Score incorporates maximum keratometry, thinnest corneal thickness, posterior elevation, and corneal aberrations, based on tomographer repeatability.

Main Results:

  • The new score demonstrated high accuracy in validation (ROC curves).
  • Younger patients showed a higher likelihood of keratoconus progression (14.3% of eyes).
  • The new score indicated crosslinking for only 2 eyes, with no observed progression post-treatment.

Conclusions:

  • The Cruces University Hospital's new progression score is based on the repeatability limit of keratoconus diagnostics.
  • This score is easily interpretable and implementable with Pentacam software.
  • It provides a numerical evaluation of anterior/posterior corneal surfaces and aberrations in keratoconus progression.