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Updated: Jun 28, 2025

High-frequency Ultrasound Imaging of Mouse Cervical Lymph Nodes
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Ultrasound fundamentals and their clinical implications for interventional cytopathologists
1Department of Pathology, UCLA, Los Angeles, California, USA.
Objective:
To describe the most important concepts in ultrasound physics that interventional cytopathologists need to understand in order to successfully perform ultrasound-guided needle biopsies.
Methods:
Review of the literature.
Results:
A deep understanding of ultrasound physics and the mathematics supporting it are not necessary. The most important concepts are frequency, attenuation, overall gain, time-gain compensation, focus, spatial resolution, temporal resolution and Doppler.
Conclusion:
By understanding these eight basic concepts of ultrasound physics and their clinical implications, interventional cytopathologists can faithfully reproduce the imaging findings of the radiologist and locate the target to precisely guide a needle for biopsy.
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