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"Could a subset of joint mobility tests define generalized joint hypermobility?": A descriptive observational
Angela Schlager1, Lena Nilsson-Wikmar2, Kerstin Ahlqvist1
1Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Plos One
|April 18, 2024
Summary
Defining generalized joint hypermobility (GJH) is challenging due to lack of consensus. This study found no single subset of joint mobility tests reliably defines GJH, suggesting a broader assessment is necessary.
Area of Science:
- Rheumatology
- Genetics
- Orthopedics
Background:
- Generalized joint hypermobility (GJH) is an inherited collagen disorder.
- Current clinical assessments lack a standardized definition and consensus on tests and limits for GJH.
- This ambiguity hinders consistent diagnosis and research.
Purpose of the Study:
- To identify a specific subset of joint mobility tests for defining GJH.
- To evaluate standardized limits for classifying hypermobility across various joint types.
- To address the lack of international consensus in GJH assessment.
Main Methods:
- 255 early pregnant women were assessed using a structured joint mobility protocol.
- Correlation and principal component analysis were employed to identify key mobility tests.
- Standard deviation levels (0.84 to 2.0) were used to define hypermobility thresholds.
Main Results:
- No single subset of joint mobility tests could definitively define GJH.
- Higher standard deviation limits correlated with lower GJH prevalence.
- Combinations of major/minor joints across limbs and axial skeleton showed variable GJH prevalence (0-12.9%) depending on limits.
Conclusions:
- Selecting a limited subset of tests to define GJH is likely not feasible.
- A comprehensive assessment including diverse joint types and sizes is recommended to avoid overlooking GJH.
- GJH prevalence is significantly influenced by the chosen hypermobility limits and test combinations.
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