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Cannabinoids regulate an insula circuit controlling water intake.

Zhe Zhao1, Ana Covelo2, Yoni Couderc2

  • 1INSERM 1215, Neurocentre Magendie, University of Bordeaux, 146 rue Léo Saignat, 33000 Bordeaux, France; Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL 33458, USA.

Current Biology : CB
|April 18, 2024
PubMed
Summary
This summary is machine-generated.

Cannabinoid type 1 (CB1) receptors in the posterior insula regulate water intake by inhibiting specific neural pathways to the amygdala, fine-tuning thirst responses.

Keywords:
BLACB(1) receptorinsular circuitsneural activitysynaptic plasticitywater intake

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Physiology

Background:

  • The insular cortex (insula) is crucial for detecting thirst and regulating water intake.
  • Detailed understanding of the insula's topographical, circuit, and molecular control of water intake is limited.

Purpose of the Study:

  • To investigate the role of cannabinoid type 1 (CB1) receptors in the insula's regulation of water intake.
  • To elucidate the circuit mechanisms underlying CB1 receptor-mediated control of water intake.

Main Methods:

  • Examined neuronal activity in the anterior insula (aIC) and posterior insula (pIC) during water intake.
  • Manipulated CB1 receptor expression in the pIC and its projections to the basolateral amygdala (BLA).
  • Utilized chemogenetics and electrophysiological recordings to assess neuronal function and synaptic plasticity.

Main Results:

  • CB1 receptors in the pIC, but not the aIC, are essential for normal water intake.
  • CB1 receptors are highly expressed in pIC-BLA projections.
  • Activation of pIC-BLA neurons decreased water intake, and CB1 signaling modulated synaptic plasticity in this pathway.

Conclusions:

  • CB1 receptor signaling in the insula promotes water intake by inhibiting the pIC-BLA pathway.
  • This mechanism contributes to the fine-tuned, top-down control of thirst.
  • The findings reveal a novel molecular and circuit basis for water homeostasis.