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Published on: April 17, 2021
The relationship between cardiac oxidative stress, inflammatory cytokine response, cardiac pump function, and
Dongpeng Duan1, Hongjun Li2, Shiyun Chai3
1Department of Emergency, Affiliated Hospital of Hebei Engineering University, Handan, Hebei, China.
Insights
Early antioxidant and anti-inflammatory treatment after myocardial infarction significantly improves cardiac function and prognosis. This intervention reduces inflammatory markers, oxidative stress, and adverse cardiac events, leading to better patient outcomes.
Area of Science:
- Cardiology
- Biochemistry
- Pharmacology
Background:
- Myocardial infarction (MI) can lead to cardiac oxidative stress and inflammation, negatively impacting cardiac function and prognosis.
- Standard treatment for MI may not fully address the underlying inflammatory and oxidative processes.
- Early intervention targeting these pathways could potentially improve patient outcomes.
Purpose of the Study:
- To investigate the effects of early antioxidant and anti-inflammatory treatment on cardiac oxidative stress, inflammatory response, cardiac pump function, and prognosis in post-myocardial infarction patients.
- To compare outcomes between patients receiving standard treatment and those receiving early combined intervention.
Main Methods:
- 276 post-MI patients were divided into a control group (standard treatment) and an observation group (standard + early antioxidant/anti-inflammatory treatment).
- Serum inflammatory factors (TNF-α, IL-1β, IL-6) were measured using ELISA.
- Cardiac oxidative stress was assessed using the Forkhead Box Protein A2 (FOX2) reagent and Total Antioxidant Status (TAS).
- Cardiac pump function was evaluated by Left Ventricular End-Diastolic Diameter (LVEDD), Left Ventricular Ejection Fraction (LVEF), and End-Systolic Diameter (ESD) via Doppler ultrasound.
Main Results:
- The observation group showed significantly lower levels of TNF-α, IL-1β, and IL-6 compared to the control group (P<0.05).
- The observation group had reduced total oxidation levels, OSI, EDD, and ESD, and higher LVEF and TAS levels (P<0.05).
- Incidences of reinfarction, heart failure, arrhythmia, and abnormal valve function were significantly lower in the observation group (P<0.05).
Conclusions:
- Early intervention with antioxidant and anti-inflammatory drugs significantly mitigates cardiac oxidative stress and inflammatory markers post-MI.
- This strategy enhances cardiac pump function (improved LVEF, reduced diameters) and improves overall prognosis.
- Timely intervention is crucial for reducing adverse cardiac events and improving long-term outcomes in myocardial infarction patients.
Abstract:
This study delves into the potential connections between cardiac oxidative stress, inflammatory cytokine response, cardiac pump function, and prognosis in individuals following myocardial infarction. A total of 276 patients were categorized into two groups: the control group (n = 130) and the observation group (n = 146), based on the drug intervention strategies. The control group received standard drug treatment, while the observation group received early drug intervention targeting antioxidant and anti-inflammatory treatment in addition to standard treatment. Serum levels of inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-9 (IL-6), were assessed using enzyme-linked immuno sorbent assay (ELISA) kits. The Forkhead Box Protein A2 (FOX2) reagent was used to determine the overall oxidation level. Left Ventricular End-Diastolic Diameter (LVEDD), Left Ventricular Ejection Fraction (LVEF), and End-Systolic Diameter (ESD) were measured using Doppler ultrasound. The observation group exhibited significantly reduced serum levels of TNF-α, IL-1β, and IL-6 compared to the control group (P < 0.05). Moreover, the observation group exerted lower total oxidation levels, OSI, EDD, and ESD compared to the control group (P < 0.05), while the LVEF and TAS levels in the observation group were higher than those in the control group (P < 0.05). Remarkably, the observation group experienced a significant reduction in the incidences of reinfarction, heart failure, arrhythmia, and abnormal valve function compared to the control group (P < 0.05). Decreased cardiac pump function and a more unfavorable prognosis were associated with elevated levels of cardiac oxidative stress and inflammatory factors (P < 0.05). Timely intervention with appropriate medications have a crucial effect in decreasing inflammatory marker levels, mitigating oxidative pressure, and enhancing cardiac pumping capacity and overall prognosis.
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