Related Experiment Video
Updated: Jul 1, 2026
Apparatus for Harvesting Tissue Microcolumns
Published on: October 25, 2018
Trichloroacetic Acid 15% Peel Alone versus in Combination with Microneedling in Patients with Acanthosis Nigricans
Shrook A Khashaba1, Salma Alaa1, Fatma Eldeeb1,2
1Dr. Khashaba, Ms. Alaa, and Dr. Eldeeb are with the Dermatology, Venereology, and Andrology Department, and Faculty of Medicine at Zagazig University in Zagazig, Egypt.
Background:
Acanthosis nigricans is a common hyperpigmentation disorder with a profound aesthetic impact. The primary concern of most patients is the cosmetic improvement, that is way there is a continuous search for the most effective cosmetic therapeutic option.
Methods:
40 acanthosis nigricans patients were included, lesions are split into equal halves; right side treated with TCA 15% peel and left side was treated with microneedling followed by TCA 15% peel, both sides were treated monthly for three months. Response to treatment was assessed by acanthosis nigricans grade improvement along with the percentage of improvement in texture and pigmentation individually.
Results:
There was statistically significant improvement in acanthosis nigricans grade after treatment in both sides. The combination side showed more improvement in terms of texture and pigmentation.
Conclusion:
Both TCA 15% alone or combined with microneedling were effective in improving acanthosis nigricans with superior results in combination modality.
