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Patients With Coronary Microvascular Dysfunction Have Less Circulating α-Klotho.

Nadia Akhiyat1, Ilke Ozcan1, Rajiv Gulati1

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|April 19, 2024
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Summary
This summary is machine-generated.

Low levels of the aging protein Klotho may indicate coronary microvascular dysfunction (CMD), a condition linked to vascular aging. This finding suggests Klotho could be a biomarker and therapeutic target for patients with early signs of cardiovascular disease.

Keywords:
coronary microvascular diseasenonobstructive coronary artery diseasevascular aging

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Area of Science:

  • Cardiology
  • Gerontology
  • Vascular Biology

Background:

  • Coronary microvascular dysfunction (CMD) is an early indicator of coronary vascular aging.
  • Klotho (α-klotho) is a circulating protein associated with physiological aging.
  • The study investigates low Klotho as a marker for vascular aging in patients with CMD but no coronary artery disease.

Purpose of the Study:

  • To determine if low Klotho levels are associated with coronary microvascular dysfunction (CMD).
  • To explore Klotho's potential as a biomarker for vascular aging in patients without significant coronary artery disease.
  • To assess the relationship between Klotho levels, endothelial progenitor cells, and CMD.

Main Methods:

  • Invasive coronary microvascular and endothelial function testing were performed on patients undergoing angiogram for chest pain.
  • CMD was defined by coronary blood flow response to acetylcholine or coronary flow reserve.
  • Circulating endothelial progenitor cells and plasma Klotho levels were analyzed using flow cytometry and ELISA, respectively.

Main Results:

  • Patients with CMD had significantly lower Klotho levels compared to those without CMD (P=0.03).
  • Low Klotho was a significant predictor of CMD, even after adjusting for traditional cardiovascular risk factors (OR, 0.80; P=0.05).
  • Higher Klotho levels correlated with increased numbers of endothelial progenitor cells, suggesting enhanced vascular regenerative potential.

Conclusions:

  • Klotho may serve as a valuable biomarker for identifying coronary microvascular dysfunction (CMD).
  • Klotho presents a potential therapeutic target for managing vascular aging and CMD, particularly in patients lacking traditional cardiovascular risk factors.