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Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Receptor-mediated Endocytosis

Receptor-mediated Endocytosis

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Related Experiment Video

Updated: Jun 28, 2025

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

Soluble Human Lectins at the Host-Microbe Interface.

Amanda L Peiffer¹, A E Dugan¹, L L Kiessling^2,3,1

¹Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;

Annual Review of Biochemistry

|April 19, 2024

Summary

This summary is machine-generated.

Human lectins, key innate immune proteins, maintain microbial balance across body sites. This review explores their roles in host-microbe interactions and the human microbiota.

Keywords:

glycans inflammatory bowel disease innate immunity intelectin lectins microbiome

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Biomimetic Materials to Characterize Bacteria-host Interactions

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

Related Experiment Videos

Last Updated: Jun 28, 2025

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

Biomimetic Materials to Characterize Bacteria-host Interactions

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

Area of Science:

Immunology
Microbiology
Biochemistry

Background:

Human lectins are crucial for host defense and maintaining microbial homeostasis.
These proteins recognize microbial glycans, influencing host-microbe interactions at various barriers.
Recent research highlights their role in managing the human microbiota, beyond acute infections.

Purpose of the Study:

To review the functions of soluble lectins at host-microbe interfaces.
To detail their glycan recognition properties.
To discuss their involvement in physiological and pathological processes related to the microbiota.

Main Methods:

Literature review of studies on soluble lectins.
Analysis of glycan recognition mechanisms.
Synthesis of findings on lectin roles in host-microbe interactions.

Main Results:

Soluble lectins exhibit diverse tissue-specific production and properties.
They play a significant role in recognizing and interacting with microbial communities.
Their influence extends to both commensal and pathogenic microbial colonization.

Conclusions:

Soluble lectins are vital for maintaining the human microbiota.
Understanding their functions is key to comprehending host-microbe dynamics.
Further research into lectin-glycan interactions can reveal new therapeutic targets.