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Tirzepatide and exercise training in obesity
Behnam Bagherzadeh-Rahmani1, Emanuele Marzetti2,3, Esmail Karami4
1Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Clinical Hemorheology and Microcirculation
|April 19, 2024
Summary
Resistance and aerobic training (RT+AT) alone improved fitness and insulin resistance in obese soldiers more than when combined with Tirzepatide. Tirzepatide supplementation did not offer additional benefits when used with exercise.
Area of Science:
- Exercise Physiology
- Metabolic Health
- Pharmacology
Background:
- Obesity and prediabetes pose significant health challenges, particularly in military populations.
- Combined exercise modalities and pharmacological interventions are explored to improve metabolic health.
- Tirzepatide is a novel therapeutic agent for managing metabolic conditions.
Purpose of the Study:
- To investigate the effects of 6 weeks of combined resistance training (RT) and aerobic training (AT) with Tirzepatide supplementation on lipid profiles, insulin resistance, anthropometric characteristics, and physical fitness in prediabetic obese soldiers.
- To compare the efficacy of exercise alone versus exercise combined with Tirzepatide.
- To evaluate different dosages of Tirzepatide in conjunction with exercise.
Main Methods:
- 61 obese men were randomized into six groups: Placebo, Tirzepatide (5mg or 2.5mg), or exercise combined with Placebo, Tirzepatide 5mg, or Tirzepatide 2.5mg.
- The exercise intervention consisted of 6 weeks of RT combined with AT, three sessions per week.
- Evaluations included anthropometrics, body composition, cardiorespiratory fitness (VO2max), muscle strength (1RM), and blood biochemistry (lipids, glucose, insulin, HOMA-IR).
Main Results:
- Combined exercise with Placebo or Tirzepatide significantly reduced body weight, BMI, waist circumference, fat mass, fasting blood glucose, LDL-C, total cholesterol, triglycerides, and HOMA-IR compared to control groups.
- HDL-C, chest press, and leg press strength significantly increased with exercise interventions.
- VO2max significantly increased, and insulin levels significantly decreased in the exercise-only group compared to placebo and Tirzepatide groups.
Conclusions:
- Six weeks of combined RT+AT alone is more effective than when combined with Tirzepatide for improving cardiorespiratory fitness, strength, and insulin modulation in prediabetic obese soldiers.
- Tirzepatide supplementation at 5mg or 2.5mg did not provide significant additional benefits when combined with exercise training.
- There was no significant difference in outcomes between the two Tirzepatide dosages when used with exercise.
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