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Updated: Jun 28, 2025

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
Published on: July 21, 2023
[The pharmacogenetics as integral part of personalized medicine: problems and prospects]
K R Amlaev1, A A Khripunova2, L L Maksimenko2
1The Federal State Budget Educational Institution of Higher Education "The Stavropol State Medical University" of Minzdrav of Russia, 355017, Stavropol, Russia, kum672002@mail.ru.
Abstract:
The article considers issues of implementation into clinical practice the principles of 5P medicine in its part of individualization of therapeutic tactics considering genetic characteristics of patients. The analysis of studies concerning influence of allelic variations on metabolism, safety and tolerance of the most often prescribed medicinal preparations was implemented. The main assumptions of pharmacogenomics were considered. Despite broad perspective of applying obtained data in clinical practice, there are a number of unresolved problems related to accessibility of genetic testing to population, ambiguity of approaches to interpretation of obtaining results, ethical issues and legal regulation.
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