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piRNAs as emerging biomarkers and physiological regulatory molecules in cardiovascular disease

Zhihua Liu1, Xi Zhao2

  • 1School of Basic Medical Sciences, Center for Precision Medicine, Kunming YanAn Hospital & Kunming University of Science and Technology, Kunming, China; Department of Biostatistics and Computational Biology, Bayer HealthCare, Harvard University, Boston, MA, USA.

Biochemical and Biophysical Research Communications
|April 19, 2024
PubMed

Insights

PIWI-interacting RNAs (piRNAs) show promise as novel biomarkers for cardiovascular diseases (CVD). Research highlights their roles in conditions like heart failure and myocardial infarction, offering new diagnostic and therapeutic avenues.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiology

Background:

  • Cardiovascular diseases (CVD) remain a significant global health challenge despite advancements.
  • Novel diagnostic biomarkers and therapeutic strategies are crucial for CVD risk reduction.
  • Non-coding RNAs (ncRNAs), particularly PIWI-interacting RNAs (piRNAs), are emerging as key players.

Purpose of the Study:

  • To provide a comprehensive review of current research on piRNAs in CVD.
  • To explore the roles of piRNAs in various cardiovascular conditions.
  • To identify potential diagnostic and therapeutic applications of piRNAs in CVD.

Main Methods:

  • Literature review of recent studies on piRNAs and CVD.
  • Analysis of piRNA involvement in myocardial hypertrophy, heart failure, myocardial infarction, and cardiac regeneration.
  • Synthesis of current understanding of piRNA functions in cardiovascular health and disease.

Main Results:

  • Growing evidence suggests piRNAs are valuable biomarkers for CVD diagnosis and treatment.
  • PiRNAs are implicated in the pathophysiology of diverse cardiovascular subtypes.
  • Functional roles of PIWI proteins and piRNAs in human cells are increasingly being elucidated.

Conclusions:

  • PiRNAs represent a promising area for developing novel diagnostic and therapeutic approaches for CVD.
  • Understanding piRNA mechanisms in cardiovascular disease can offer new clinical perspectives.
  • Further research into piRNAs may lead to improved management of cardiovascular conditions.

Keywords:
BiomarkerCardiovascular diseaseMechanism regulationpiRNA

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