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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Related Experiment Video

Updated: Jun 28, 2025

Reusable Single Cell for Iterative Epigenomic Analyses

Reusable Single Cell for Iterative Epigenomic Analyses

Published on: February 11, 2022

Single Cell Atlas: a single-cell multi-omics human cell encyclopedia.

Lu Pan¹, Paolo Parini^2,3, Roman Tremmel^4,5

¹Institute of Environmental Medicine, Karolinska Institutet, 171 65, Solna, Sweden.

|April 19, 2024

Summary

This summary is machine-generated.

Scientists created a comprehensive human tissue atlas using single-cell multi-omics data. This interactive online atlas provides deep insights into cell signatures across fetal and adult tissues for research.

Keywords:

Flow cytometry Human database Mass cytometry Multi-omics Single Cell Atlas Single-cell ATAC-sequencing Single-cell RNA-sequencing Single-cell immune profiling Single-cell omics Spatial transcriptomics

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Last Updated: Jun 28, 2025

Reusable Single Cell for Iterative Epigenomic Analyses

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Published on: February 11, 2022

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Published on: March 12, 2021

Isolation of Nuclei from Flash-Frozen Liver Tissue for Single-Cell Multiomics

Isolation of Nuclei from Flash-Frozen Liver Tissue for Single-Cell Multiomics

Published on: December 9, 2022

Area of Science:

Genomics and Bioinformatics
Human Tissue Biology
Multi-omics Research

Background:

Single-cell sequencing is crucial for understanding cellular heterogeneity.
Existing atlases lack comprehensive multi-omics and spatial data for human tissues.

Purpose of the Study:

To construct a single-cell multi-omics map of human tissues.
To develop an interactive web-based platform for exploring this data.
To provide a comprehensive resource for omics studies.

Main Methods:

Integration of datasets from five single-cell omics technologies.
Inclusion of spatial transcriptomics and two bulk omics datasets.
Characterization of 125 healthy adult and fetal human tissues.

Main Results:

Creation of a detailed single-cell multi-omics map of human tissues.
Development of the Single Cell Atlas (SCA) web platform (www.singlecellatlas.org).
Enabling interactive exploration of multi-omics signatures across tissue types and developmental stages.

Conclusions:

The Single Cell Atlas offers unprecedented resolution into human tissue composition.
The platform serves as a centralized, time-effective resource for diverse omics research.
Facilitates deeper understanding of human biology and disease mechanisms.