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Updated: Jun 28, 2025
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Targeting MicroRNA in myopia: Current insights
Zihao Zhuang1, Licheng Li1, Yang Yu1
1Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Engineering Research Centre of Assistive Technology for Visual Impairment, Fujian Province University, Quanzhou, Fujian, China.
Abstract:
Myopia, the most prevalent eye condition, has sparked notable interest regarding its origin and prevention. MicroRNAs (miRNAs) are short, non-coding RNA strands typically consisting of 18-24 nucleotides. They play a central role in post-transcriptional gene regulation and are closely associated with both normal and pathological processes in organisms. Recent advances in next-generation sequencing and bioinformatics have provided novel insights into miRNA expression and its regulatory role in myopia. This review discusses the distinct expression patterns, regulatory functions, and potential pathways of miRNAs involved in the onset and progression of myopia. The primary objective of this review was to provide valuable insights into molecular mechanisms underlying myopia and the contribution of miRNAs. These insights are expected to pave the way for further exploration of the molecular mechanisms, diagnosis, treatment, and clinical applications of myopia.
Insights
This review explores microRNAs (miRNAs), small molecules regulating genes, and their role in myopia development. Understanding these molecular mechanisms could lead to new myopia diagnosis and treatments.
Area of Science:
- Ophthalmology
- Molecular Biology
- Genetics
Background:
- Myopia is a prevalent eye condition with complex origins.
- MicroRNAs (miRNAs) are key regulators of gene expression.
- Recent advances enable studying miRNA roles in myopia.
Purpose of the Study:
- To review the distinct expression patterns of miRNAs in myopia.
- To elucidate the regulatory functions and pathways of miRNAs in myopia onset and progression.
- To provide insights into the molecular mechanisms underlying myopia.
Main Methods:
- Literature review of next-generation sequencing and bioinformatics studies.
- Analysis of distinct miRNA expression patterns.
- Discussion of miRNA regulatory functions and potential pathways.
Main Results:
- miRNAs exhibit distinct expression patterns in myopia.
- Specific miRNAs are involved in the molecular mechanisms of myopia.
- miRNAs play a significant role in post-transcriptional gene regulation related to myopia.
Conclusions:
- miRNAs are crucial in the molecular mechanisms of myopia.
- Further research into miRNA pathways can advance myopia diagnosis and treatment.
- Understanding miRNA contributions may lead to novel clinical applications for myopia.
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