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Updated: Jun 28, 2025
Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
Four-year mortality and physical activity in Japanese patients with chronic obstructive pulmonary disease
Seiichi Kobayashi1, Fumi Chiba2, Masatsugu Ishida1
1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, 71 Nishimichishita, Hebita, Ishinomaki, 986-8522, Japan.
Background:
Physical activity (PA) is associated with the risk of mortality in patients with chronic obstructive pulmonary disease (COPD); however, evidence is limited to the Japanese population. This study aimed to evaluate the effects of PA on long-term mortality in Japanese patients with COPD.
Methods:
We conducted a prospective observational study in a cohort of Japanese patients with COPD and assessed mortality during a 4-year follow-up period. The Cox proportional hazards model was used to evaluate the association between PA and mortality.
Results:
Among 309 patients (294 men; median age, 76 years), 287 completed follow-ups while 45 died. The all-cause mortality rate was 27.5% in patients with low PA and 4.1% in those with high PA. Adjusted hazard ratios for all-cause mortality were associated with high PA.
Conclusions:
Higher PA levels are associated with a better prognosis across different settings and patient characteristics, even in Japanese patients with COPD.
Trial Registration:
The study was registered in the UMIN Clinical Trials Registry (UMIN000032112).
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