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Updated: Jun 28, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

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Ligand bias and inverse agonism on 5-HT2A receptor-mediated modulation of G protein activity in post-mortem human

Itziar Muneta-Arrate1,2,3, Patricia Miranda-Azpiazu1,2, Igor Horrillo1,2,4

  • 1Department of Pharmacology, University of the Basque Country UPV/EHU, Leioa, Spain.

British Journal of Pharmacology
|April 22, 2024
PubMed
Abstract

Keywords:
5‐HT2A receptorG protein[35S]GTPγSconstitutive activityfunctional selectivityinverse agonismpost‐mortem brain

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