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Published on: May 2, 2012
Effects of Oxygen Therapy on Patients with a Chronic Wound: A Systematic Review and Meta-analysis
Xinyan Du1, Xuena Zhang, Junxia Liu
1At the Fourth Hospital of Hebei Medical University, Shijiazhuang, China, Xinyan Du, BSN, RN, is Deputy Chief Nursing Officer, Outpatient Dressing Room; Xuena Zhang, BSN, RN, is Nurse Practitioner in Charge, Second Department of General Surgery; Junxia Liu, BSN, RN, is Deputy Chief Nursing Officer, Department of Infectious Diseases; and Zhendi Wang, BSN, RN, is Nursing Officer, Outpatient Dressing Room. Acknowledgments: This study was funded as a medical science research project of Hebei Provincial Health Commission (project number ZD20140109). The authors have disclosed no other financial relationships related to this article. Submitted September 29, 2022; accepted in revised form May 17, 2023.
Objective:
To synthesize the effects of oxygen-based therapy on patients with a chronic wound.
Data Sources:
The authors searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials for relevant randomized controlled trials from database inception. Investigators measured risk of bias using the Cochrane Collaboration's Risk of Bias tool.
Study Selection:
The included randomized controlled trials focused on the effects (short- or long-term wound healing, amputation rate, percentage of reduction in ulcer size, and poststudy transcutaneous oxygen measurement [TcPO2]) of oxygen-based therapy (including hyperbaric oxygen therapy, topical oxygen therapy, and continuous diffusion of oxygen) on patients with a chronic wound.
Data Extraction:
Researchers extracted information regarding participant characteristics and primary and secondary outcomes from the included studies.
Data Synthesis:
Pooled effects of 31 included studies showed that patients treated with oxygen had better short-term wound healing (risk ratio [RR], 1.544; 95% CI, 1.199 to 1.987), a higher percentage reduction in the ulcer area (standardized mean difference [SMD], 0.999; 95% CI, 0.439 to 1. 599), lower amputation rates (RR, 0.529; 95% CI, 0.325 to 0.862), shorter wound healing time (SMD, -0.705; 95% CI, -0.908 to -0.501), and higher poststudy TcPO2 (SMD, 2.128; 95% CI, 0.978 to 3.278) than those in the control group. For long-term wound healing, there was no statistically significant difference (RR, 1.227; 95% CI, 0.976 to 1.542).
Conclusions:
Oxygen-based therapy improves short-term parameters of wound healing in patients with chronic wounds.
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