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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Is pre-diabetes a predictor of events in patients with atrial fibrillation?

Ana Ledo Piñeiro1, Emad Abu-Assi1, Inmaculada González Bermúdez2

  • 1Department of Cardiology, University Hospital Álvaro Cunqueiro, Vigo, Spain; Health Research Institute Galicia Sur, Vigo, Spain.

International Journal of Cardiology
|April 22, 2024
PubMed

Insights

In patients with atrial fibrillation (AF) and pre-diabetes, elevated glycated hemoglobin (HbA1c) levels did not correlate with increased risk of ischemic or bleeding events. This study found no association between pre-diabetes ranges of HbA1c and worse prognosis in non-diabetic AF patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Diabetes mellitus (DM) is a known risk factor for atrial fibrillation (AF) and its associated ischemic strokes.
  • Limited data exists on the association between glycated hemoglobin (HbA1c) and adverse events in patients with pre-diabetes and AF.

Purpose of the Study:

  • To investigate if pre-diabetes, indicated by HbA1c levels, predicts ischemic events, bleeding events, myocardial infarction, or mortality in non-diabetic patients with AF.

Main Methods:

  • A retrospective study analyzed 2993 non-diabetic AF patients, categorized into normal glucose (n=1351) and pre-diabetes (n=1642) groups based on HbA1c.
  • Incidence rates per 100 person-years were compared between groups.
  • Competitive hazard regression and Cox regression analyses were used to assess risks.

Main Results:

  • No significant differences in incidence rates of various events were observed between the normal glucose and pre-diabetes groups.
  • Analysis of HbA1c as a continuous variable also showed no association with increased event risk, even after adjusting for CHA2DS2-VASc and HAS-BLED scores.

Conclusions:

  • In a cohort of 2993 non-diabetic patients with new-onset AF, pre-diabetes defined by HbA1c levels was not associated with a worse prognosis regarding ischemic or bleeding events.
Abstract

Keywords:
Atrial fibrillationIschemic strokePre-diabetes

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