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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Related Experiment Video

Updated: Jun 28, 2025

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
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The association between oxidized low-density lipoprotein and cancer: An emerging targeted therapeutic approach?

Samin Ghorbani Moghadam1, Mehrshad Ebrahimpour1, Seyedeh Hoda Alavizadeh2

  • 1Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Bioorganic & Medicinal Chemistry Letters
|April 22, 2024
PubMed
Summary

Elevated low-density lipoprotein (LDL) and oxidized LDL (ox-LDL), along with their receptors like LOX-1, are linked to cancer progression. Targeting these pathways offers a promising therapeutic strategy for various cancers.

Keywords:
AutophagyCarcinogenesisLDL nanoparticlesLOX-1Ox-LDL

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Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Lipids, including low-density lipoprotein (LDL) and oxidized LDL (ox-LDL), are crucial for cellular functions like growth and division.
  • Elevated LDL, ox-LDL, and their receptors (LDLR, LOX-1, CD36) correlate with cancer hallmarks such as proliferation, invasion, and angiogenesis.
  • High serum LOX-1 levels are a poor prognostic indicator in several cancers, including colorectal cancer.

Purpose of the Study:

  • To review the role of oxidized LDL (ox-LDL) and LOX-1 in cancer progression, invasion, metastasis, and angiogenesis.
  • To explore the therapeutic potential of targeting the ox-LDL/LOX-1 pathway in cancer treatment.

Main Methods:

  • Literature review of studies investigating the role of LDL, ox-LDL, and their receptors in carcinogenesis.
  • Analysis of therapeutic strategies involving repurposed drugs, phytochemicals, autophagy modulators, and nanoparticles targeting the ox-LDL/LOX-1 pathway.

Main Results:

  • Ox-LDL contributes to cancer progression and metastasis via endothelial-to-mesenchymal transition (EMT) and autophagy.
  • Targeting ox-LDL/LOX-1 pathways using various agents shows potential for cancer therapy.
  • Several compounds have demonstrated efficacy in targeting metabolic moieties involved in cancer progression.

Conclusions:

  • Targeting LDL and ox-LDL represents a significant therapeutic avenue for cancer treatment.
  • Further research into these metabolic targets holds promise for future biomedical applications in oncology.