Antibody drug conjugates: Design implications for clinicians
Stephanie Pang1, Arianne Duong1, Chloe Siu1
1Department of Pharmacy, University of Washington, Seattle, WA, USA.
Summary
Pharmacists play a crucial role in managing antibody-drug conjugates (ADCs) in oncology. Understanding ADC pharmacokinetics, drug interactions, and adverse effects is essential for patient care.
Area of Science:
- Pharmacology
- Oncology
- Drug Development
Background:
- Antibody-drug conjugates (ADCs) are increasingly utilized in oncology.
- 11 ADCs are currently FDA-approved, with more in development.
Purpose of the Study:
- To review the pharmacokinetic profiles of ADC components.
- To guide pharmacist practitioners on practical considerations for ADC therapy.
- To discuss ADCs in organ dysfunction, drug-drug interactions, and adverse effect management.
Main Methods:
- Systematic literature search of ADCs through September 2023.
- Review of clinical trials, ADC design, functional components, adverse effects, and pharmacokinetics.
- Inclusion of prescribing information, tertiary, and primary literature.
Main Results:
- Overview of 11 FDA-approved ADCs, including mechanisms of action and structure.
- Description of ADC toxicity mechanisms and structural implications.
- Guidance on managing ADCs in specific clinical scenarios.
Conclusions:
- Pharmacist understanding of ADC design and function is critical for oncology patient care.
- Knowledge of ADCs aids in comparing adverse effect profiles and supporting multidisciplinary teams.
- Pharmacists can enhance patient education and management of ADC therapy.
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