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Updated: Jun 28, 2025

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Remote Radical Azidation of Unactivated C(sp3)-H Bonds in Sulfamoyl Azides
Jiawei Li1, Sishi Zhong1, Pan Zhou1
1School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China.
Abstract:
An efficient method for remote radical C(sp3)-H azidation at unactivated sites is described. C-H functionalization proceeds via intramolecular 1,5-hydrogen atom transfer to N-centered radicals that are generated via azido group transfer and/or fragmentation. The readily installed sulfamoyl azide serves as both an amidyl radical precursor and an azido source. This reaction features excellent site selectivity for tertiary, secondary, primary, and benzylic C(sp3)-H bonds and exhibits broad functional group compatibility.
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