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Updated: Jun 28, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.9K
Adherence, persistence and treatment switching in psoriasis
Fiorenzo Santoleri1, Felice Musicco2, Chiara Fulgenzio2
1ASL Pescara, Hospital Pharmacy.
Immunotherapy
|April 23, 2024
Summary
Treatment adherence for psoriasis drugs was good, but long-term persistence declined after three years. Improving patient persistence is crucial for effective psoriasis management.
Area of Science:
- Dermatology
- Pharmacoeconomics
- Real-world evidence
Background:
- Psoriasis (PsO) is a chronic inflammatory disease requiring long-term management.
- Understanding drug utilization patterns is key to optimizing patient outcomes.
- Several biologic and non-biologic therapies are available for PsO treatment.
Purpose of the Study:
- To evaluate drug utilization, specifically adherence and persistence, for major psoriasis treatments.
- To analyze these patterns over a 5-year period in a real-world setting.
- To identify areas for improvement in long-term psoriasis management.
Main Methods:
- Utilized data from an observational study.
- Assessed treatment adherence using the Proportion of Days Covered (PDC) method.
- Evaluated treatment persistence over 1 to 5 years.
Main Results:
- Good adherence was observed for all studied drugs (Adalimumab, Etanercept, Ustekinumab, Golimumab, Ixekizumab, Secukinumab, Apremilast).
- Treatment persistence was suboptimal and decreased significantly from year 3 onwards.
- Adherence remained stable, while persistence showed a declining trend over time.
Conclusions:
- While adherence to psoriasis therapies is generally good, long-term persistence is a challenge.
- Strategies to improve patient persistence are needed for sustained efficacy in psoriasis management.
- Further research should focus on factors influencing long-term treatment persistence in PsO.
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