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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

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Capture and Release of Viable Circulating Tumor Cells from Blood
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Microfluidic-SERS Technologies for CTC: A Perspective on Clinical Translation.

Amin Hassanzadeh-Barforoushi1, Anastasiia Tukova1, Audrey Nadalini1

  • 1School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, New South Wales 2109, Australia.

ACS Applied Materials & Interfaces
|April 23, 2024
PubMed
Summary

Integrating microfluidics with surface-enhanced Raman scattering (SERS) offers a powerful new system for isolating, enumerating, and detecting circulating tumor cells (CTCs). This approach promises to advance cancer diagnosis and treatment monitoring by providing sensitive, multiplexed analysis of CTCs.

Keywords:
Cancercancer detectioncirculating tumor cellsepithelial-to-mesenchymal transitionmetastasismicrofluidicssurface-enhanced Raman scattering

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Oncology

Background:

  • Circulating tumor cells (CTCs) are crucial biomarkers for cancer diagnosis and treatment monitoring.
  • Current methods for CTC analysis require integrated systems for efficient isolation and sensitive phenotypic evaluation.
  • Surface-enhanced Raman scattering (SERS) offers multiplexing capabilities for molecular profiling and cancer diagnosis.

Purpose of the Study:

  • To explore the combined potential of microfluidics and SERS for CTC isolation, enumeration, and detection.
  • To discuss the key operational factors for integrating microfluidic CTC processing with SERS detection.
  • To highlight the clinical utility of microfluidic-SERS integration for cancer diagnosis and prognostication.

Main Methods:

  • Development of an integrated system combining microfluidics for high-throughput single-cell processing and SERS for sensitive, multiplexed quantitation.
  • Analysis of key operational factors in microfluidic CTC isolation and SERS detection from patient samples.
  • Discussion of the integration of microfluidic and SERS techniques for clinical translation.

Main Results:

  • Microfluidics enables efficient isolation and manipulation of CTCs.
  • SERS provides sensitive and multiplexed detection of clinically relevant signals from CTCs.
  • Integrated microfluidic-SERS systems demonstrate potential for advanced CTC analysis.

Conclusions:

  • The integration of microfluidics and SERS represents a significant advancement in CTC analysis.
  • This combined approach offers a paradigm shift for clinical CTC-based cancer diagnosis and prognostication.
  • Further development is needed to translate this technique into routine clinical applications.