Musculoskeletal Biorepository: Establishment, Sustainment, and Tips for Success

Area of Science:

• Biomedical research
• Genomics
• Proteomics

Background:

• Biorepositories, or biobanks, are collections of biological samples for laboratory research.
• Precision medicine increasingly relies on individual biomolecular signatures for improved diagnosis, prognosis, and treatment.
• The development of biorepositories holds potential for transformative preclinical research.

Purpose of the Study:

• To highlight the importance of biorepositories in advancing precision medicine and orthobiologics research.
• To outline the team-based approach required for establishing and operating a biobank.
• To emphasize the role of biobanks in multiomics studies for musculoskeletal diseases.

Main Methods:

• Coordinated team approach involving research laboratory staff and regulatory bodies.
• Systematic execution of research activities including case identification, consent, and specimen collection/processing/storage.
• Application of multiomics approaches (genomic, transcriptomic, proteomic, microbiomic).

Main Results:

• Successful biorepository development enables transformative preclinical research.
• A coordinated team approach is essential for efficient biobank operations.
• Biobanks facilitate novel inquiries into musculoskeletal diseases via multiomics.

Conclusions:

• Biorepositories are vital for leveraging individual biomolecular signatures in precision medicine.
• Effective biobank management requires a collaborative, multidisciplinary team.
• Biobanks are essential for advancing orthobiologics and understanding musculoskeletal diseases through multiomics.