Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multi-site feasibility of a web-based and telephone navigation intervention to connect lung cancer caregivers in community oncology settings with resources: Protocol for the WF-2301CD caregiver oncology needs evaluation tool (CONNECT) trial.

Contemporary clinical trials·2026

Same author

Low-Frequency Adaptive Deep Brain Stimulation for Parkinson's Disease.

medRxiv : the preprint server for health sciences·2026

Same author

Endometrial cancer somatic testing practice patterns among gynecologic oncologists.

Gynecologic oncology·2025

Same author

"If You're Talking, I Think You're Muted": Follow-up Analysis of Weekly Peer Review Discussion and Plan Changes After Transitioning From Virtual to In-Person Format.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024

Same author

Beta Burst-Driven Adaptive Deep Brain Stimulation Improves Gait Impairment and Freezing of Gait in Parkinson's Disease.

medRxiv : the preprint server for health sciences·2024

Same author

Cortical stimulation leads to shortened myelin sheaths and increased axonal branching in spared axons after cervical spinal cord injury.

Glia·2023

Same journal

Assessment Metrics for Pain Control in Rats: A Methodological Commentary.

Journal of neuroscience methods·2026

Same journal

Infant EEG preprocessing pipelines: a capability framework and current gaps in practice.

Journal of neuroscience methods·2026

Same journal

Methods for Measuring Neural Activity During Voluntary Wheel Running.

Journal of neuroscience methods·2026

Same journal

Serotype-dependent differences in AAV cellular transduction rates in the hypothalamus of Arctic ground squirrels.

Journal of neuroscience methods·2026

Same journal

Rapid generation of human sensory neurons from iPSC for modeling of peripheral neuropathies.

Journal of neuroscience methods·2026

Same journal

BAMBI: A Ca<sup>2+</sup> imaging-based brain-computer interface for longitudinal neuronal tracking in freely behaving mice.

Journal of neuroscience methods·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 28, 2025

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Data processing techniques impact quantification of cortico-cortical evoked potentials.

L H Levinson¹, S Sun², C J Paschall²

¹University of Washington Graduate Program in Neuroscience, 1959 NE Pacific Street, T-47, Seattle, WA 98195-7270, United States.

Journal of Neuroscience Methods

|April 23, 2024

Summary

This summary is machine-generated.

Processing electrophysiology data, like cortico-cortical evoked potentials (CCEPs), significantly impacts results. Careful application of filters and re-referencing is crucial for accurate quantification of CCEP connectivity.

Keywords:

Cortico-cortical evoked potential Effective connectivity Electrocorticography Evoked potential Neural data analysis Preprocessing

More Related Videos

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

Published on: January 29, 2014

Infant Auditory Processing and Event-related Brain Oscillations

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Related Experiment Videos

Last Updated: Jun 28, 2025

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities

Published on: January 29, 2014

Infant Auditory Processing and Event-related Brain Oscillations

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Area of Science:

Neuroscience
Electrophysiology

Background:

Cortico-cortical evoked potentials (CCEPs) are vital for studying human brain connectivity.
CCEP data is susceptible to noise, necessitating preprocessing.
Current preprocessing strategies vary across studies.

Purpose of the Study:

To systematically evaluate the impact of common preprocessing techniques on CCEP quantification.
To compare the effects of filtering and re-referencing on CCEP data.

Main Methods:

Systematic comparison of common average re-referencing and various filtering techniques.
Analysis of CCEP magnitude and morphology changes due to preprocessing.

Main Results:

Common average re-referencing and aggressive filtering significantly alter CCEP quantification.
Filtering is more effective than re-referencing or trial averaging in noise reduction.
Specific filter cutoffs (>0.5 Hz high-pass, <200 Hz low-pass) and common average re-referencing notably impact results.

Conclusions:

Existing CCEP processing methods require careful application to balance noise reduction and data integrity.
Reporting preprocessing methods, especially re-referencing, is essential.
A framework for selecting appropriate CCEP processing pipelines based on noise levels is proposed, favoring minimal filtering.