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Related Experiment Video

Updated: May 11, 2026

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Biomechanical changes in keratoconus after customized stromal augmentation.

Sana Niazi1,2, Jorge Alió Del Barrio3, Farideh Doroodgar1,2

  • 1Translational Ophthalmology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Taiwan Journal of Ophthalmology
|April 24, 2024
PubMed
Summary

Stromal augmentation with small-incision lenticule extraction (SMILE) lenticules significantly alters corneal biomechanics in advanced keratoconus (KCN) patients. This study quantifies these changes using Corvis ST, showing improved corneal stiffness and structural integrity post-procedure.

Keywords:
Corneacorneal stromakeratoconusstromal lenticuletissue donorstransplantation

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Area of Science:

  • Ophthalmology
  • Biomechanical Engineering
  • Corneal Surgery

Background:

  • Advanced keratoconus (KCN) involves progressive thinning and weakening of the cornea.
  • Current treatments aim to halt progression and improve visual acuity.
  • Small-incision lenticule extraction (SMILE) lenticules offer a potential option for stromal augmentation in KCN.

Purpose of the Study:

  • To evaluate the biomechanical effects of stromal augmentation using SMILE lenticules in advanced KCN patients.
  • To assess changes in corneal parameters measured by Corvis ST after lenticule implantation.

Main Methods:

  • A clinical trial included 22 advanced KCN patients who received implanted lenticules (>100 μ).
  • Corvis ST was used to measure biomechanical parameters at 3, 6, and 24 months post-implantation.
  • Analysis included applanation events, concavity changes, and Vinciguerra screening parameters, with regression analyses for correlating factors.

Main Results:

  • Significant improvements in corneal stiffness (e.g., increased HC time, SP-A1) and central corneal thickness were observed.
  • Corneal deformation parameters (e.g., HC deformation amplitude, CBI) showed significant decreases.
  • Mean spherical equivalent and keratometry values improved post-procedure.

Conclusions:

  • Stromal augmentation with SMILE lenticules induces significant and measurable changes in corneal biomechanics in advanced KCN.
  • These findings suggest potential for SMILE lenticules in managing advanced keratoconus by enhancing corneal structural integrity.