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Related Experiment Video

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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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A comprehensive review on corneal crosslinking.

Andrea Naranjo1, Edward E Manche1

  • 1Department of Ophthalmology, The Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.

Taiwan Journal of Ophthalmology
|April 24, 2024
PubMed
Summary

Corneal crosslinking (CXL) is a safe and effective treatment for corneal ectatic disorders, halting disease progression. This minimally invasive procedure strengthens the cornea, improving patient quality of life with long-lasting results.

Keywords:
Corneacross-linkingectasiakeratoconusriboflavin

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering

Background:

  • Corneal ectatic disorders historically required specialized contact lenses or corneal transplantation.
  • Corneal crosslinking (CXL) offers a novel therapeutic approach.

Purpose of the Study:

  • To evaluate the efficacy and safety of corneal crosslinking (CXL) in managing corneal ectatic disorders.
  • To review the biochemical mechanism and clinical outcomes of CXL.

Main Methods:

  • Utilizing ultraviolet A light and Riboflavin to induce biochemical crosslinks in corneal stromal collagen.
  • Comparing various CXL protocols, including epithelium-on and epithelium-off techniques with differing light parameters.

Main Results:

  • CXL effectively strengthens and stabilizes the cornea by increasing collagen crosslinking.
  • Clinical data demonstrate a halt in disease progression, evidenced by stabilized keratometry readings.
  • Reported complications are minimal, including infection, stromal haze, scarring, and endothelial toxicity.

Conclusions:

  • Corneal crosslinking (CXL) is a safe, effective, and minimally invasive treatment for corneal ectatic disorders.
  • The procedure leads to mechanical stiffening of the cornea, halting disease progression and improving patient quality of life.
  • CXL is a cost-effective outpatient procedure with fast recovery and durable outcomes.