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Comparing femtosecond LASIK and small-incision lenticule extraction (SMILE)
Aneesha Ahluwalia1, Edward E Manche
1Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Current Opinion in Ophthalmology
|April 25, 2025
Summary
Femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small-incision lenticule extraction (SMILE) offer comparable vision correction for myopia and astigmatism. Customized FS-LASIK may provide superior visual outcomes, while SMILE shows potential benefits for dry eye and corneal stability.
Area of Science:
- Ophthalmology
- Refractive Surgery
- Corneal Surgery
Background:
- Refractive surgery aims to correct vision by reshaping the cornea.
- Femtosecond laser-assisted in situ keratomileusis (FS-LASIK) and small-incision lenticule extraction (SMILE) are advanced laser vision correction techniques.
- Comparing these modalities is crucial for optimizing patient outcomes.
Purpose of the Study:
- To compare FS-LASIK and SMILE based on efficacy, safety, recovery, and patient-reported outcomes.
- To provide an updated review of recent scientific findings.
- To identify research gaps for improving surgical results and patient selection.
Main Methods:
- Systematic review of recent comparative studies on FS-LASIK and SMILE.
- Analysis of visual outcomes, safety profiles, postoperative recovery, and patient satisfaction.
- Evaluation of corneal biomechanical stability and dry eye incidence.
Main Results:
- Both FS-LASIK and SMILE achieve excellent visual outcomes for myopia and astigmatism.
- SMILE may reduce dry eye risk and eliminate flap complications; FS-LASIK offers faster visual recovery.
- Customized FS-LASIK (wavefront/topography-guided) may outperform SMILE in specific visual metrics like uncorrected visual acuity and higher-order aberration reduction.
Conclusions:
- FS-LASIK is a gold standard due to rapid recovery and predictability.
- SMILE offers benefits in corneal biomechanics and potentially reduced dry eye symptoms, with possible long-term stability advantages.
- Evidence suggests customized FS-LASIK may yield superior visual outcomes; further long-term comparative studies are needed.

