Related Experiment Video
Updated: Jun 28, 2025
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot
Ning Zhang1, Kun Peng1, Jin-Xia Guo2
1Department of Radiology, The Sixth Hospital of Shanxi Medical University (General Hospital of TISCO), Taiyuan, People's Republic of China.
Study Objectives:
We assessed possible brain abnormalities in adult patients with moderate and severe obstructive sleep apnea using the mean kurtosis (MK) from diffusion kurtosis imaging and analyzed the correlation between MK and cognitive function.
Methods:
A total of 30 patients with moderate or severe obstructive sleep apnea and 30 healthy controls evaluated by the Montreal Cognitive Assessment scale were enrolled. All participants underwent diffusion kurtosis imaging and 3-dimensional T1-weighted imaging on a 3.0T magnetic resonance scanner. The MK values of gray and white matter brain regions were compared. Partial correlation analysis was used to analyze the correlation between respiratory sleep parameters/cognitive score and MK values in different brain regions.
Results:
Compared with the healthy controls, the MK of 20 brain regions (13 after false discovery rate correction) and cognitive scores in the obstructive sleep apnea group were significantly lower. In the obstructive sleep apnea group, apnea-hypopnea index was negatively correlated with the MK in the white matter of the right occipital lobe; lowest oxygen saturation was positively correlated with the MK in the bilateral parietal, precentral, and right postcentral cortex; total score on the Montreal Cognitive Assessment scale was positively correlated with MK in the left hippocampus; language function was positively correlated with MK in the white matter of the left parietal lobe; and delayed recall was positively correlated with the MK in right insula cortex and bilateral cingulate. After false discovery rate correction, only the correlations of lowest oxygen saturation with right precentral gyrus cortex and bilateral parietal cortex were significant.
Conclusions:
MK values of diffusion kurtosis imaging may provide valuable information in assessing the neurological impacts of obstructive sleep apnea.
Citation:
Zhang N, Peng K, Guo J-X, Liu Q, Xiao A-L, Jing H. Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot study with diffusion kurtosis imaging. J Clin Sleep Med. 2024;20(10):1571-1578.
Insights
Diffusion kurtosis imaging revealed brain abnormalities in patients with obstructive sleep apnea (OSA). Mean kurtosis (MK) values were lower in OSA patients, correlating with cognitive function deficits.
Area of Science:
- Neuroimaging
- Sleep Medicine
- Neurology
Background:
- Obstructive sleep apnea (OSA) is linked to cognitive impairment.
- Diffusion kurtosis imaging (DKI) offers insights into brain microstructure.
Purpose of the Study:
- To assess brain abnormalities in moderate to severe OSA patients using DKI.
- To analyze the correlation between mean kurtosis (MK) and cognitive function in OSA.
Main Methods:
- 30 OSA patients and 30 controls underwent DKI and 3D T1-weighted MRI.
- Montreal Cognitive Assessment (MoCA) scale evaluated cognitive function.
- Partial correlation analysis examined relationships between MK, sleep parameters, and cognition.
Main Results:
- OSA patients showed significantly lower MK in 13 brain regions (post-FDR correction) and lower cognitive scores.
- Apnea-hypopnea index negatively correlated with white matter MK.
- Lowest oxygen saturation positively correlated with cortical MK.
Conclusions:
- DKI-derived MK values may indicate neurological damage in OSA.
- MK shows potential for assessing the brain's response to OSA.
