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Related Concept Videos

Brain Imaging01:14

Brain Imaging

228
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
228

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Microstructural brain abnormalities and associated neurocognitive dysfunction in obstructive sleep apnea: a pilot

Ning Zhang1, Kun Peng1, Jin-Xia Guo2

  • 1Department of Radiology, The Sixth Hospital of Shanxi Medical University (General Hospital of TISCO), Taiyuan, People's Republic of China.

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
|April 24, 2024
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Diffusion kurtosis imaging revealed brain abnormalities in patients with obstructive sleep apnea (OSA). Mean kurtosis (MK) values were lower in OSA patients, correlating with cognitive function deficits.

Keywords:
cognitive functiondiffusion kurtosis imagingobstructive sleep apnea

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Area of Science:

  • Neuroimaging
  • Sleep Medicine
  • Neurology

Background:

  • Obstructive sleep apnea (OSA) is linked to cognitive impairment.
  • Diffusion kurtosis imaging (DKI) offers insights into brain microstructure.

Purpose of the Study:

  • To assess brain abnormalities in moderate to severe OSA patients using DKI.
  • To analyze the correlation between mean kurtosis (MK) and cognitive function in OSA.

Main Methods:

  • 30 OSA patients and 30 controls underwent DKI and 3D T1-weighted MRI.
  • Montreal Cognitive Assessment (MoCA) scale evaluated cognitive function.
  • Partial correlation analysis examined relationships between MK, sleep parameters, and cognition.

Main Results:

  • OSA patients showed significantly lower MK in 13 brain regions (post-FDR correction) and lower cognitive scores.
  • Apnea-hypopnea index negatively correlated with white matter MK.
  • Lowest oxygen saturation positively correlated with cortical MK.

Conclusions:

  • DKI-derived MK values may indicate neurological damage in OSA.
  • MK shows potential for assessing the brain's response to OSA.