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PTIP UFMylation promotes replication fork degradation in BRCA1-deficient cells

Qunsong Tan1, Xingzhi Xu2

  • 1Guangdong Key Laboratory for Genome Stability & Disease Prevention and Carson International Cancer Center, Marshall Laboratory of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.

The Journal of Biological Chemistry
|April 24, 2024
PubMed
Summary

Homologous recombination deficiency in breast cancer cells can be targeted by PARP inhibitors. PTIP UFMylation promotes DNA degradation at stalled replication forks, conferring chemoresistance in BRCA1-deficient cells.

Keywords:
BRCA1PTIPUFMylationend resectionreplication fork

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