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Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Acute Kidney Injury V: Interprofessional Care01:20

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Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
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Acute Dapagliflozin Administration Ameliorates Cardiac Surgery-Associated Acute Kidney Injury in a Rabbit Model.

Kensaku Matsuda1, Hiroshi Mitsuo1, Takuya Nishijima1

  • 1Department of Cardiovascular Surgery, Kyushu University Hospital.

Circulation Journal : Official Journal of the Japanese Circulation Society
|April 24, 2024
PubMed
Summary

Sodium-glucose cotransporter-2 inhibitors like dapagliflozin show promise in preventing acute kidney injury (AKI) after cardiac surgery. This study found dapagliflozin protected rabbit kidneys from cardiopulmonary bypass-induced AKI.

Keywords:
Acute kidney injuryCardiopulmonary bypassDapagliflozinRabbit modelReactive oxygen species

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Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Sodium-glucose cotransporter-2 inhibitors (SGLT2i) demonstrate renoprotective effects in acute kidney injury (AKI).
  • The efficacy of SGLT2i in preventing cardiac surgery-associated AKI remains largely unexplored.

Purpose of the Study:

  • To investigate the renoprotective potential of dapagliflozin in a rabbit model of cardiac surgery-associated AKI.

Main Methods:

  • Acute kidney injury was induced in rabbits via cardiopulmonary bypass (CPB).
  • Dapagliflozin was administered intravenously prior to CPB.
  • Renal function, tubular injury, oxidative stress, inflammation, and apoptosis were assessed.

Main Results:

  • Dapagliflozin significantly reduced serum creatinine and blood urea nitrogen levels.
  • It increased urine output and improved tubular injury scores.
  • Dapagliflozin mitigated oxidative stress and inflammation, while promoting antioxidant pathways.

Conclusions:

  • Acute intravenous dapagliflozin administration effectively protects against CPB-induced AKI in rabbits.
  • Dapagliflozin may exert direct renoprotective effects on renal tubular cells.