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[The clinical evaluation of ceftizoxime suppositories in the pediatric field]
Insights
Ceftizoxime suppository (CZX-S) effectively treats pediatric bacterial infections like bronchitis and UTI. This new rectal antibiotic showed good patient tolerability and clinical outcomes.
Area of Science:
- Pediatric infectious diseases
- Pharmacokinetics and drug efficacy
- Antibiotic therapy
Background:
- Bacterial infections in children require effective and well-tolerated treatments.
- Ceftizoxime suppository (CZX-S) is a novel rectal formulation for pediatric use.
Observation:
- Clinical evaluation of CZX-S in 5 pediatric cases with acute bronchitis, tonsillitis, UTI, and pertussis.
- Blood levels of CZX ranged from 3.26-23.3 µg/ml within 10-20 minutes post-administration (10.0-26.3 mg/kg dose).
- Urinary excretion rates within 6 hours were measured (15.2-60.2%).
Findings:
- Excellent clinical effects were observed in 3 cases, and good effects in 2 cases.
- One case showed slight elevation in GOT and GPT; no other adverse effects were noted.
- Patients demonstrated good tolerability to the rectal suppository formulation.
Implications:
- Ceftizoxime suppository (CZX-S) demonstrates significant utility in treating various pediatric bacterial infections.
- The favorable pharmacokinetic profile and clinical efficacy suggest CZX-S as a valuable therapeutic option.
- Good tolerability supports the use of CZX-S in pediatric patients where oral administration may be challenging.
Abstract:
Clinical evaluation of ceftizoxime suppository (CZX-S), a new antibiotic rectal suppository, was performed in 5 cases with bacterial infections in pediatric field (2 with acute bronchitis, 1 with acute tonsillitis, UTI and pertussis, respectively) and the following results were obtained; Blood levels of CZX at 10-20 minutes after administration of CZX-S at a dose of 10.0-26.3 mg/kg in 5 cases were 3.26-23.3 micrograms/ml and the urinary excretion rates within 6 hours were 15.2, 60.1, 60.2% in 3 of 5 cases measured respectively. Clinical effects were excellent in 3 and good in 2 cases. Slight elevation of GOT and GPT was observed in 1 case. No other side effects were observed. The patients' tolerability against rectal suppository was good. From the above results, we concluded that CZX-S is useful for treating the pediatric patients with various infections.